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A Study of Solbinsiran (LY3561774) in Participants With Severe Hypertriglyceridemia
A Study of Solbinsiran (LY3561774) in Participants With Severe Hypertriglyceridemia

NCT07269210

RecruitingPhase 2

Sponsor: Eli Lilly and Company

Conditions: Severe Hypertriglyceridemia

Interventions: Solbinsiran, Placebo

Countries: United States, Canada, China, Japan

The purpose of this study is to evaluate the safety and efficacy of solbinsiran in lowering triglycerides and other lipid measures compared to placebo in participants with severe hypertriglyceridemia. Participants will receive two subcutaneous injections.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria
Inclusion Criteria:

* History of fasting triglyceride levels of ≥500 milligrams per deciliter (mg/dL), based on medical history
* Fasting triglyceride level ≥500 mg/dL at two separate visits during screening (at least 7 days apart)
* Have a body mass index (BMI) within the range of 18.5 to 45.0 kilograms per square meter (kg/m2) (inclusive)

Exclusion Criteria:

* Have had a major atherosclerotic cardiovascular event within the past 3 months prior to screening
* Have a known genetically confirmed diagnosis of Familial Chylomicronemia Syndrome
* Have a history of or planned treatment involving any gene editing or gene therapy modalities, including but not limited to CRISPR-based, viral vector-mediated, or other genetic modification techniques
* Have a history of chronic alcohol abuse within 3 years prior to screening
Locations (41)
  • Phoenix, Arizona, United States
  • Tucson, Arizona, United States
  • Beverly Hills, California, United States
  • Long Beach, California, United States
  • Montclair, California, United States
  • Northridge, California, United States
  • Hamden, Connecticut, United States
  • Jacksonville, Florida, United States
  • Miami, Florida, United States
  • Miami Lakes, Florida, United States
  • Winter Park, Florida, United States
  • Chicago, Illinois, United States
  • Brownsburg, Indiana, United States
  • Covington, Kentucky, United States
  • Bowie, Maryland, United States
  • Worcester, Massachusetts, United States
  • Las Vegas, Nevada, United States
  • Pennington, New Jersey, United States
  • New York, New York, United States
  • New York, New York, United States
  • Houston, Texas, United States
  • Mesquite, Texas, United States
  • San Antonio, Texas, United States
  • San Antonio, Texas, United States
  • Lynchburg, Virginia, United States
  • Newport News, Virginia, United States
  • Roanoke, Virginia, United States
  • Redmond, Washington, United States
  • Seattle, Washington, United States
  • Chicoutimi, Canada
  • + 11 more on CT.gov