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Evaluation of the Clinical Contribution of Quantitative MRI in Neuro-imaging

Not Yet RecruitingNA

Sponsor: Assistance Publique Hopitaux De Marseille

Conditions: Multiple Sclerosis

Interventions: 3T MRI, 7T MRI, Clinical examination of MS patients, Neuropsychological testing of MS patients, Quality of life questionnaires

Countries: France

This study aims to develop the use of a quantitative MRI (qMRI) approach in neuroimaging for MS patients. To achieve this task the main goals of this study will be: * to standardize and optimize qMRI protocols (acquisition time, sensitivity) * to acquire ranges of normative values of qMRI parameters as a function of age and sex at high fields (3 Tesla) and ultra-high fields (UHF for ultra-high field, 7 Tesla) * To develop integrated tools for image processing and the generation of normative models of the healthy brain normative values * To assess the clinical feasibility and the multicenter validation of the multiparametric tools proposed in the case of application to MS.

Eligibility overview

Sex: ALL

Age: 18 Years to 52 Years

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* For healthy volunteers :

  * Male or female aged 20 to 50
  * Subject with no history of previous or concomitant neurological and psychiatric diseases at the time of inclusion
  * Subject without a history of traumatic brain injury
  * Subject with no vascular history (arterial hypertension, stroke) or concomitant at the time of its inclusion
  * Subject has no history of chronic drug and/or alcohol abuse
  * Subject having received information regarding the study and having signed an informed consent
  * Beneficiary or entitled person to a social security scheme
* For MS patients

  * Male or female aged 18 to 52
  * Patient diagnosed with MS according to the
  * criteria of McDonald 2017
  * Patient presenting a maximum EDSS of 6
  * Patient with MS for less than 10 years of evolution
  * Patient having received information regarding the study and having signed an informed consent
  * Patient beneficiary or entitled to a plan of social security

Exclusion Criteria:

* For healthy subjects :

  * Subject presenting a contraindication to performing an MRI: pacemaker, presence of metal implants, claustrophobia.
  * Subject unable to maintain a supine position for a prolonged period
  * Subject in a period of exclusion from another research protocol at the time of signing consent/non-opposition form
  * Subjects covered by articles L1121-5 to 1121-8 of the Public Health Code (minor patient, adult patient under guardianship or curatorship, patient deprived of liberty, pregnant or breastfeeding woman)
* For MS patients

  * Subject presenting a contraindication to performing an MRI: pacemaker, presence of metal implants, claustrophobia.
  * Subject unable to maintain a supine position for a prolonged period
  * Subject in a period of exclusion from another research protocol at the time of signing consent/non-opposition form
  * Subjects covered by articles L1121-5 to 1121-8 of the Public Health Code (minor patient, adult patient under guardianship or curatorship, patient deprived of liberty, pregnant or breastfeeding woman)

Locations (1)

Montpellier, France