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MS Synchronous vs Asynchronous Exercise Study

CompletedNA

Sponsor: Yeditepe University

Conditions: Multiple Sclerosis, Multiple Sclerosis (MS) - Relapsing-remitting

Interventions: Combined Exercise Program (Synchronous Delivery), Combined Exercise Program (Asynchronous Delivery)

Countries: Turkey (Türkiye)

This randomized controlled study aims to compare the effects of synchronous and asynchronous exercise programs on individuals diagnosed with relapsing-remitting multiple sclerosis (RRMS). Participants meeting the inclusion criteria (EDSS score between 2 and 5.5, aged 18-55) were randomly assigned to either the Synchronous Exercise Group (SEG) or the Asynchronous Exercise Group (ASEG). The synchronous program was delivered via live online sessions using Google Meet and WhatsApp video calls, while the asynchronous program consisted of pre-recorded exercise videos accessible to participants. Both programs included structured exercises focusing on functional capacity, muscle strength, fatigue, independence, and quality of life. The sample size was determined using G\*Power software based on previous studies in individuals with multiple sclerosis, targeting a total of 16. Statistical analyses will be conducted using SPSS 26.0. Parametric and non-parametric tests will be used depending on data distribution, with significance set at p \< 0.05. The study seeks to improve accessibility to exercise programs for MS patients and provide evidence for the efficacy of remotely delivered synchronous versus asynchronous rehabilitation models.

Eligibility overview

Sex: ALL

Age: 18 Years to 55 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Diagnosis of Relapsing-Remitting Multiple Sclerosis (RRMS) according to the McDonald criteria.
* Age between 18 and 55 years.
* Expanded Disability Status Scale (EDSS) score between 2.0 and 5.5.
* No relapse within the last six months.
* Access to the necessary technological infrastructure (internet, camera, and microphone) to participate in the synchronous exercise program.

Exclusion Criteria:

* Presence of any neurological diagnosis other than MS.
* Any vestibular, cardiovascular, or orthopedic condition that limits exercise participation or increases fall risk (Jallouli et al., 2022).
* Mini-Mental State Examination (MMSE) score below 24.
* Timed Up and Go (TUG) test result greater than 14.2 seconds, indicating elevated fall risk (Block et al., 2022).
* Severe visual or auditory impairments.
* Presence of a psychiatric diagnosis.
* Current participation in another exercise or physiotherapy/rehabilitation program.
* Pregnancy.

Locations (1)

Istanbul, Ataşehir, Turkey (Türkiye)