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Effects of Grape Consumption on the Immune-Gut Axis in Obesity

RecruitingNA

Sponsor: University of Missouri-Columbia

Conditions: Obesity &Amp; Overweight

Interventions: Freeze-dried grape powder, Placebo powder

Countries: United States

This study is investigating the benefits of whole freeze-dried grape powder consumption on the immune-gut axis in adults with obesity.

Eligibility overview

Sex: ALL

Age: 18 Years to 60 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Age: 18-60 years
* Obesity with BMI of 30-45 kg/m2
* Willingness to consume study foods
* Consistent diet and activity patterns for 4 weeks
* Weight stable (\<5kg change over last 3 months)
* Non-smoker \> 1 year or more
* Not currently consuming an extremely healthy diet

Exclusion Criteria:

* Study food allergies
* Regular consumption of grapes or grape-derived products
* Gastrointestinal disease and/or bariatric surgery
* Uncontrolled hypertension and blood pressure \>180/110
* Diabetes
* Illicit drug use
* History of alcohol or drug abuse
* Recent use of medications that affect immune function (e.g., corticosteroids)
* Recent consumption of antibiotics, prebiotics, probiotics, symbiotics, or dietary supplements containing fiber or phytochemicals
* Pregnant or lactating individuals
* HIV positivity
* Recent start of medications that affect metabolism or appetite
* Drug therapy for coronary artery disease, peripheral artery disease, congestive

Locations (1)

Columbia, Missouri, United States