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Radiation Therapy (RT) for Parkinson's Disease (PD)

Enrolling By InvitationNA

Sponsor: Mayo Clinic

Conditions: Parkinson's Disease

Interventions: Radiation therapy

Countries: United States

The purpose of this study is to investigate the use of ultra-low, anti-inflammatory doses of radiation therapy (RT) for the treatment of Parkinson's Disease (PD). In this study, the TrueBeam LINAC utilizes a linear accelerator (LINAC) for the delivery of radiation therapy. Dynamic conformal arc (DCA) therapy will be used to deliver a total of five (5) once-a-day radiation treatments (RT) using DaT-SPECT (Dopamine Transporter-Single-Photon Emission Computed Tomography) and MRI imaging to guide radiation treatment planning.

Eligibility overview

Sex: ALL

Age: 45 Years to 70 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria

* Age ≥ 45 and ≤ 70 years
* Diagnosis of Parkinson's disease by a Movement Disorder Neurologist
* Confirmation of unilateral Parkinson's disease by Dopamine Transporter (DaT) scan
* A score of 2 or less on the modified Hoehn and Yahr scale
* ECOG Performance Status (PS) ≤ 2 (Appendix I).
* No known genetic causes or predisposition to Parkinson's disease or related diseases.
* Ability to complete questionnaires, neurological exam, and follow-up imaging independently or with assistance
* Ability to provide written informed consent
* Willing to provide mandatory blood samples for correlative research purposes
* Willing to return to enrolling institution for follow-up

Exclusion Criteria

* Concomitant dementia diagnosis or concerns of other memory disorder
* Parkinson's Disease medication changes within the last 3 months
* Receipt of radiation therapy for Parkinson's Disease outside Mayo Clinic, Rochester

Locations (1)

Rochester, Minnesota, United States