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A Long-Term Study of Navenibart in Participants With Hereditary Angioedema

NCT07204938

Enrolling By InvitationPhase 3

Sponsor: Astria Therapeutics, Inc.

Conditions: Hereditary Angioedema (HAE)

Interventions: navenibart

Countries: United States, Brazil, Bulgaria, Canada, Czechia, France, Germany, Hong Kong

This is a Phase 3 multicenter trial in 2 parts to evaluate the long-term safety and efficacy of navenibart in adult and adolescent participants with hereditary angioedema (HAE) who participated in STAR-0215-301 (NCT06842823; ALPHA-ORBIT). Part 1 provides all participants with navenibart in a dose-controlled fashion; Part 2 introduces a personalized dosing option (PDO) for participants based on individual needs.

Eligibility overview

Sex: ALL

Age: 12 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

1\. Participants from STAR-0215-301 who met one of the following conditions:

1. Completed STAR-0215-301 through the Day 181 visit
2. Withdrew from STAR-0215-301 but met the following criteria:

i. Received 2 doses of IP ii. completed ≥ 2 months of trial follow-up after the second dose of IP iii. Met other eligibility criteria as assessed by Investigator

Exclusion Criteria:

1. Participation in an investigational clinical trial other than STAR-0215- 301 in the 30 days or any exposure to an investigational drug (other than navenibart in STAR-0215-301) within 5 half-lives before informed consent/assent
2. Any exposure to angiotensin-converting enzyme (ACE) inhibitors or any estrogen containing medications with systemic absorption (such as hormonal contraceptives or hormone replacement therapy) within 30 days before Screening.
3. Known sensitivity to the ingredients in the formulation of IP

Locations (40)

Scottsdale, Arizona, United States
Little Rock, Arkansas, United States
San Diego, California, United States
Santa Monica, California, United States
Walnut Creek, California, United States
Centennial, Colorado, United States
Colorado Springs, Colorado, United States
Wheaton, Maryland, United States
Cincinnati, Ohio, United States
Hershey, Pennsylvania, United States
Santo André, Brazil
Sofia, Bulgaria
Edmonton, Canada
Prague, Czechia
Paris, France
Frankfurt, Germany
Hong Kong, Hong Kong
Ashkelon, Israel
Haifa, Israel
Petah Tikva, Israel
Petah Tikva, Israel
Milan, Italy
Monserrato, Italy
Kawagoe, Saitama, Japan
Fukuoka, Japan
Kawasaki, Japan
Amsterdam, Netherlands
Skopje, North Macedonia
Krakow, Poland
Rzeszów, Poland
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