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Kappa Free Light Chains (KFLC) in Multiple Sclerosis (MS) and Clinically Isolated Syndrome (CIS)

Enrolling By InvitationN/A

Sponsor: Skripuletz, Thomas Prof. Dr.

Conditions: Multiple Sclerosis, Clinically Isolated Syndrome (CIS)

Interventions: Oligoclonal bands and kappa free light chains (KFLC)

Countries: Germany

The goal of this observational study is to learn about the role of kappa free light chains (KFLC) in cerebrospinal fluid (CSF) in the diagnosis of multiple sclerosis (MS) and clinically isolated syndrome (CIS). The main question it aims to answer is: Are KFLC superior, inferior or equally useful in the diagnostic work-up of CSF of patients with MS and CIS? In CSF and serum sample pairs of patients diagnosed with MS or CIS, KFLC are measured using a nephelometric assay and are compared with the gold standard, of CSF diagnostics, oligoclonal bands.

Eligibility overview

Sex: ALL

Age: 18 Years to 70 Years

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* patients diagnosed with multiple sclerosis (MS) or clinically isolated syndrome (CIS) according to 2017-revised McDonald criteria for MS
* age between 18 and 70 years

Exclusion Criteria:

* no diagnosis of MS or CIS according to 2017-revised McDonald criteria for MS
* no available cerebrospinal fluid (CSF) and serum sample pairs

Locations (1)

Hanover, Lower Saxony, Germany