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Testing of an Interface for Synchronizing tACS-DBS With a Phase-locked-loop

CompletedNA

Sponsor: Universitätsklinikum Hamburg-Eppendorf

Conditions: Deep Brain Stimulation, Parkinson's Disease (PD)

Interventions: DBS-coupled tACS

Countries: Germany

The investigators aim to test an interface to phase-lock transcranial alternating current stimulation (tACS) and deep brain stimulation (DBS) for future studies investigating the effects of different time-lags between DBS and tACS on the behavioural and neural level. To test if the interface works in patients with DBS, the investigators record EEG during synchronized tACS-DBS in several patients. The investigators hypothesize that they can apply tACS at the desired phase-lags relative to DBS pulses and confirm this with EEG measurements of the DBS and tACS artifact.

Eligibility overview

Sex: ALL

Age: 35 Years to 85 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Provision of written informed consent by the patient
* Age 35 - 85
* patient groups: Parkinson's disease, essential tremor, dystonia
* \>3 months after surgery for DBS

Exclusion Criteria:

* Epilepsy or history of seizures
* Existence of heart pacemaker or other metal implants in the body (except DBS)
* Pregnancy

Locations (1)

Hamburg, Germany