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Cortical Inhibition in Patients With Multiple Sclerosis

Not Yet RecruitingN/A

Sponsor: Assiut University

Conditions: Multiple Sclerosis

Interventions: Clinical and Demographic Assessment, Corticospinal Inhibition Assessment, Radiological Assessment

1. To investigate the relationship between corticospinal inhibition and clinical, psychological, and cognitive features in MS patients. 2. To examine the association between corticospinal inhibition and radiological findings, including MRI lesions and white matter damage

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

1. Age 18 years or older.
2. Diagnosis of RRMS based on the 2017 McDonald Criteria.
3. Expanded Disability Status Scale (EDSS) score ≤ 6.5.
4. On a stable dose of disease-modifying therapy (DMT) for at least 3 months or naeive patients not use DMT before
5. Free of relapses or steroids treatment (at least 3 months after a relapse or corticosteroid therapy)
6. Ability to give informed consent and complete neuropsychological assessments.

Exclusion Criteria:

1. Presence of other neurological or psychiatric disorders (e.g., major depression, bipolar disorder, schizophrenia).
2. History of alcohol or substance abuse.
3. Contraindications to MRI (e.g., pacemakers, metallic implants) and TMS (i.e., history of seizures, presence of ferromagnetic implants in the head area).
4. Medications known to alter the corticospinal excitability.
5. Severe visual deficit, motor weakness, or intellectual impairment (as per the Mini-Mental State Exam score \< 24).