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Effects of EXOPULSE Mollii Suit on Spasticity and Functionality in Multiple Sclerosis Patients

Not Yet RecruitingNA

Sponsor: Hacettepe University

Conditions: Multiple Sclerosis

Interventions: EXOPULSE Mollii Suit + Exercise, EXOPULSE Mollii Suit

Spasticity affects \>80% of MS patients, with 35-54% experiencing moderate-to-severe symptoms, impairing mobility and sleep. Electrical stimulation parameters (e.g., high vs. low frequency) for spasticity management remain debated. The EXOPULSE Mollii Suit uses non-invasive, low-frequency stimulation to induce reciprocal inhibition and modulate spinal interneuron activity, potentially reducing spasticity. This study aims to compare EXOPULSE Mollii + exercise vs. EXOPULSE Mollii alone in improving spasticity and function in MS.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Diagnosed with MS by a neurologist according to McDonald criteria
* Age \>18 years
* EDSS score ≤6.5 (able to walk independently without assistive devices)
* Presence of spasticity
* Mini Mental State Examination (MMSE) score ≥24

Exclusion Criteria:

* Received surgical intervention or botulinum toxin injection for spasticity within the last 6 months
* Presence of any neurological condition (other than MS) that may affect independent standing or walking
* Currently participating in another rehabilitation program
* Declined to participate or provide written informed consent