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Serum 25-Hydroxyvitamin D and Neurological Disability in Multiple Sclerosis

CompletedN/A

Sponsor: University of Zintan

Conditions: Multiple Sclerosis

Countries: Libya

Vitamin D is hypothesized to play a role in the immunopathology and progression of multiple sclerosis (MS), yet its association with neurological disability remains uncertain, particularly in North African populations.We conducted a cross-sectional study involving 369 adult MS patients across two tertiary neurology centers in Western Libya. Serum 25-hydroxyvitamin D \[25(OH)D\] levels and Expanded Disability Status Scale (EDSS) scores were collected. Pearson correlation, ANOVA, and multivariable linear regression were used to assess associations between vitamin D and disability, adjusting for age, BMI, disease duration, and physical activity. Missing data and outliers were handled systematically using validated R and Python workflows.

Eligibility overview

Sex: ALL

Age: 18 Years to 70 Years

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* Libyan nationals.
* aged 18 years or older.
* diagnosis of MS based on the 2017 revised McDonald criteria.
* capable of providing informed consent.
* had complete clinical, demographic, and biochemical data.

Exclusion Criteria:

* presence of other neurological disorders that could mimic MS (e.g., neuromyelitis optica spectrum disorder or Lyme disease).
* missing or incomplete medical records.
* pregnancy or lactation.
* extreme psychiatric or cognitive impairment.

Locations (1)

Tripoli, Tripoli, Libya