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Memory Deterioration in Alzheimer Disease

NCT07118137

RecruitingN/A

Sponsor: Norwegian University of Science and Technology

Conditions: Alzheimer Disease, Neurodegenerative Diseases, Magnetic Resonance Imaging, Memory Impairment

Interventions: 7T MRI, EEG, Blood samples, Stool samples, Neuropsychologic test (MoCA)

Countries: Norway

Semantic AD

Eligibility overview

Sex: ALL

Age: 55 Years to —

Healthy volunteers: Yes

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* Confirmed diagnosis based on current ICD criteria for AD or MCI .
* \>55years.
* Norwegian native speaker
* Lives at home and not in a health institution

Exclusion Criteria:

* Patients with severe cognitive impairment that prevents assessment with the selected modalities (planned cut-off: CDR \> 2).
* Presence of brain tumors.
* History of traumatic brain injury.
* History of cranial surgery.
* Contraindications to the selected imaging modalities (e.g., 7T MRI or EEG).
* Diagnosis of other neurodegenerative diseases such as Parkinson's disease or ALS.

  7T MRI contraindications:
* Large tattoos close to the head region, permanent makeup or unremoveable piercings
* Certain models of pacemakers (if pacemaker implantet, MRI physicist at 7T-lab will be conferred)
* Implantet metal in body (clips, stents, prothesis, skrews, plates, teeth etc.)

Locations (1)

Trondheim, Trønderlag, Norway