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Efficacy of Gamma Auditory Stimulation for Cognitive Decline in Older Adults (Study 1)

RecruitingNA

Sponsor: Chang Gung Memorial Hospital

Conditions: EEG Brain Oscillations, Alzheimer's Disease (AD) and Related Disorders, Cognitive Dysfunction

Interventions: Gamma auditory stimulation device (active setting), Gamma auditory stimulation device (sham setting)

Countries: Taiwan

Animal studies have shown that 40 Hz auditory stimulation alone can improve spatial memory and reduce Aβ deposition. However, human studies using 40 Hz auditory stimulation alone remain limited. Therefore, this study will use a randomized, double-blind, placebo-controlled design to investigate the effects of 40 Hz auditory stimulation on cognitive function, EEG activity, sleep quality, and quality of life in older adults with mild cognitive impairment (MCI) or mild dementia.

Eligibility overview

Sex: ALL

Age: 60 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

1. Age over 60 years old.
2. MMSE≤ 24
3. CDR scores of 0.5 and 1
4. Voluntary to sign the Informed Consent Form.

Exclusion Criteria:

1. Diagnosis of other psychiatric or neurological disorders
2. Drug or alcohol addictions.
3. Serious heart, liver or kidney disorders, and visual, auditory or motor impairments interfering with neuropsychological tests.
4. History of clinical stroke, major depressive disorder or dysthymic disorder according to the DSM-5.

Locations (1)

Taoyuan, Guishan, Taiwan