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A Study to Learn About How a New Pneumococcal Vaccine Works in Adults
A Study to Learn About How a New Pneumococcal Vaccine Works in Adults

NCT07086677

Active Not RecruitingPhase 1

Sponsor: Pfizer

Conditions: Streptococcus Pneumoniae

Interventions: PG4 vaccine in Buffer 1 with low dose PA-001, PG4 in Buffer 1 with low dose PA-002, PG4 in Buffer 1 with high dose PA-001, PG4 vaccine in Buffer 1 with high dose PA-002, PG4 vaccine in Buffer 2

Countries: United States

The purpose of this study is to learn about the safety and tolerability of a pneumococcal vaccine in adults. Participants will receive either: * an experimental PG4 vaccine * a PG4 vaccine comparator * a standard 20vPnC vaccine comparator * placebo. A placebo does not have any medicine in it but looks just like the study medicine. Participants will take part in this study for up to 18 months depending on which group they are assigned to. During this time, the participants will receive up to two doses of study vaccine or comparator and take part in follow-up visits. At these clinic visits, participants will be asked if any side effects were experienced. The participants will also have to give blood samples during clinic visits.

Eligibility overview

Sex: ALL

Age: 65 Years to 84 Years

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria
Key Inclusion Criteria:

* Healthy participants who are determined by medical history, physical examination (if required), and clinical judgment of the investigator to be eligible for inclusion in the study.
* Participants either with no history of ever receiving a pneumococcal vaccine or who have received a pneumococcal vaccine more than 5 years prior to vaccination in this study

Key Exclusion Criteria:

• Participants with a history of microbiologically proven invasive disease caused by S pneumoniae.
Locations (20)
  • Lake Forest, California, United States
  • Rolling Hills Estates, California, United States
  • Greenacres City, Florida, United States
  • Miami Lakes, Florida, United States
  • Lenexa, Kansas, United States
  • Springfield, Missouri, United States
  • Springfield, Missouri, United States
  • Springfield, Missouri, United States
  • Omaha, Nebraska, United States
  • East Syracuse, New York, United States
  • New York, New York, United States
  • Durham, North Carolina, United States
  • Cincinnati, Ohio, United States
  • Brownsville, Texas, United States
  • Brownsville, Texas, United States
  • Houston, Texas, United States
  • San Antonio, Texas, United States
  • Tomball, Texas, United States
  • Salt Lake City, Utah, United States
  • Salt Lake City, Utah, United States