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Preventing Early-Onset Colorectal Cancer in the VA
Preventing Early-Onset Colorectal Cancer in the VA

NCT07071454

Not Yet RecruitingNA

Sponsor: VA Office of Research and Development

Conditions: Colorectal Neoplasms, Mass Screening

Interventions: Patient intervention, PCP intervention

Countries: United States

Colorectal cancer is a leading cause of cancer death among Veterans. The starting age for colorectal cancer screening has been lowered from 50 to 45 years in response to the rising incidence of early-onset colorectal cancer (EOCRC), but how to best engage younger Veterans in screening is unclear. The investigators will 1) develop and validate a novel risk score for EOCRC derived from the VA electronic health record data, 2) conduct a multilevel screening intervention that targets individuals aged 45-49 years and informs high-risk individuals and their providers about their risk status for EOCRC, and 3) determine barriers and facilitators to implementing the intervention using a qualitative process evaluation. Aim 2 is the focus of the trial. The overall goal of this study is to create and test a risk stratification approach to prevent EOCRC, which may be especially useful for younger individuals who are less likely to participate in preventive care.

Eligibility overview

Sex: ALL

Age: 45 Years to 49 Years

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria
Inclusion Criteria:

* Age 45-49 years at screening

Exclusion Criteria:

* Up-to-date with CRC screening based on the USPSTF guideline (e.g., colonoscopy within the past 10 years or FIT within the past year)
* Prior CRC diagnosis
* Prior total colectomy
* Limited life expectancy (defined as terminal illness, hospice enrollment, or documented life expectancy \<6 months on the medical problem list or a health factor in the EHR
* Deactivated national CRC screening and surveillance reminder (due to risk level or comorbidities)
Locations (1)
  • New York, New York, United States