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Upper Body Subcutaneous Exosome Release in Response to a Meal in Obesity

RecruitingNA

Sponsor: Mayo Clinic

Conditions: Obesity

Interventions: Meal Study

Countries: United States

The purpose of this study is to understand the specific outflow and difference between normal weight and volunteers with obesity of upper body subcutaneous adipose tissue in response to a mixed meal challenge by site specific cannulation of the superior epigastric vein. We will characterize the exosome signatures in response to a meal and compare to the exosome signature of arterialized venous plasma samples.

Eligibility overview

Sex: ALL

Age: 18 Years to 55 Years

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

• All women must be premenopausal

Exclusion Criteria:

* Participants taking medications know to affect blood flow (statins, β-blockers) or fatty acid or adipose tissue metabolism (TZDs, high dose fish oil supplements)
* Diabetes, history of cardiovascular disease
* Allergy to lidocaine
* Post-menopausal women
* Pregnant

Locations (1)

Rochester, Minnesota, United States