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A Master Protocol for Orforglipron (LY3502970) in Participants With Obesity or Overweight With and Without Type 2 Diabetes
A Master Protocol for Orforglipron (LY3502970) in Participants With Obesity or Overweight With and Without Type 2 Diabetes

NCT06993792

Active Not RecruitingPhase 3

Sponsor: Eli Lilly and Company

Conditions: Obesity, Overweight, Type 2 Diabetes

Interventions: Orforglipron, Placebo

Countries: United States, Argentina, China, Czechia, Germany, Japan, Puerto Rico

The purpose of this Master Protocol is to support two studies to see how well and how safely orforglipron works compared to placebo in participants who have obesity or overweight with or without type 2 diabetes. Participants will be screened for about 4 weeks, after which they will enroll into either J2A-MC-GZP1, NCT06972459 (do not have type 2 diabetes) or J2A-MC-GZP2, NCT06972472 (have type 2 diabetes).

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria
There are no specific eligibility criteria for the Master Protocol.

* See study GZP1 for eligibility criteria relevant to participants with obesity and overweight without type 2 diabetes
* See study GZP2 for eligibility criteria relevant to participants with type 2 diabetes
Locations (80)
  • Sun City West, Arizona, United States
  • Tucson, Arizona, United States
  • San Ramon, California, United States
  • Santa Ana, California, United States
  • Thousand Oaks, California, United States
  • DeLand, Florida, United States
  • Fort Lauderdale, Florida, United States
  • Hialeah, Florida, United States
  • Hollywood, Florida, United States
  • Ocoee, Florida, United States
  • Tampa, Florida, United States
  • Winter Park, Florida, United States
  • Decatur, Georgia, United States
  • Decatur, Georgia, United States
  • Savannah, Georgia, United States
  • Woodstock, Georgia, United States
  • Meridian, Idaho, United States
  • New Iberia, Louisiana, United States
  • Rockville, Maryland, United States
  • Silver Spring, Maryland, United States
  • Bay City, Michigan, United States
  • Missoula, Montana, United States
  • Carson City, Nevada, United States
  • Las Vegas, Nevada, United States
  • Chapel Hill, North Carolina, United States
  • Charlotte, North Carolina, United States
  • Fayetteville, North Carolina, United States
  • Corvallis, Oregon, United States
  • Philadelphia, Pennsylvania, United States
  • Smithfield, Pennsylvania, United States
  • + 50 more on CT.gov