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Sponsor: University of Campania Luigi Vanvitelli
Conditions: Mild Cognitive Impairment, Alzheimer Disease, Parkinson
Countries: Italy
The aim of this longitudinal observational study is to evaluate the impact of sensory deficits (smell, hearing and balance on cognitive decline and quality of life in the medium term (5 years)) on a population of patients over 55. Patients will be evaluated by a neurologist, a neuropsychologist and an otolaryngologist who will perform olfactory, auditory and vestibular tests. The acquired data will then be analyzed with multivariate analysis to understand the effect of multisensory deficit on both cognition and quality of life with a particular focus on depression. The primary objective will be the evaluation of multiple deficits on cognition, the secondary will be aimed at understanding whether one sensory deficit more than another, e.g. smell versus hearing, will have a greater impact on the patient's conditions.
Sex: ALL
Age: 60 Years to 85 Years
Healthy volunteers: No
Study type: OBSERVATIONAL
Inclusion Criteria: * Patients between 60 and 85 years of age * in general good health * the absence of known severe psychiatric disorders * available to be included in the study and * to follow the 5-year follow-up. Exclusion Criteria: * Obstructive nasal problems * Previous endoscopic nose + paranasal sinus surgery * Chronic use of cortisone spray and/or systemic * Subjects with previous stroke and outcomes * Subjects with history of stroke in the last 3 years without outcomes * Head trauma in the last 24 months * Previous ear surgery * Patients who have been exposed to chemical agents without protection for work, e.g. carpenters * previous Covid with outcomes (olfactory, vestibular, auditory and cognitive "brain fog")
- Naples, Campania, Italy