Trial Radar
Sign in

NCT lookup

Pull any trial record directly from ClinicalTrials.gov.

A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)
A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)

NCT06991257

RecruitingPhase 2

Sponsor: Pfizer

Conditions: Heart Failure

Interventions: Placebo, Low Dose PF-07328948, Medium Dose PF-07328948, High Dose PF-07328948

Countries: United States, Brazil, Bulgaria, Canada, China, Czechia, France, Hungary

The purpose of this study is to learn about the safety and effects of the study medicine (PF-07328948) for the possible treatment of heart failure (HF).

Eligibility overview

Sex: ALL

Age: 18 Years to 79 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria
This study is seeking participants who are:

Key Inclusion Criteria include:

* aged 18 years to \< 80 years
* clinically confirmed to have a diagnosis of heart failure for at least 3 months
* New York Heart Association Class II-IV symptoms
* left ventricular ejection fraction greater than 40%
* Kansas City Cardiomyopathy Questionnaire-23 Total Symptom Score \< 85
* Six-minute walking distance greater than 75 meters

Key Exclusion Criteria include:

* Type 1 diabetes mellitus, liver cirrhosis or any condition that can possibly affect how the medicine is absorbed into the body.
* Major surgery scheduled for the duration of the study, affecting walking ability in the opinion of the study doctor.
* History of heart transplantation, or currently listed for a heart transplant, or current planned use of IV vasodilators and/ or inotropes
* Prior intolerance/known hypersensitivity to an SGLT2 inhibitor or contraindication to an SGLT2 inhibitor
Locations (142)
  • Beverly Hills, California, United States
  • Lake Forest, California, United States
  • Santa Maria, California, United States
  • Santa Maria, California, United States
  • Boca Raton, Florida, United States
  • Jacksonville, Florida, United States
  • Miami, Florida, United States
  • Miami, Florida, United States
  • North Miami Beach, Florida, United States
  • Winter Park, Florida, United States
  • Chicago, Illinois, United States
  • Chicago, Illinois, United States
  • Chicago, Illinois, United States
  • Chicago, Illinois, United States
  • Chicago, Illinois, United States
  • Evanston, Illinois, United States
  • Hazel Crest, Illinois, United States
  • Fort Wayne, Indiana, United States
  • Richmond, Indiana, United States
  • Baltimore, Maryland, United States
  • Bowie, Maryland, United States
  • Bowie, Maryland, United States
  • Lincoln, Nebraska, United States
  • Lima, Ohio, United States
  • Brownsville, Texas, United States
  • Brownsville, Texas, United States
  • McKinney, Texas, United States
  • Tomball, Texas, United States
  • Brasília, Federal District, Brazil
  • Brasília, Federal District, Brazil
  • + 112 more on CT.gov