NCT lookup

Pull any trial record directly from ClinicalTrials.gov.

A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and at Least One Weight-Related Comorbidity

NCT06972459

Active Not RecruitingPhase 3

Sponsor: Eli Lilly and Company

Conditions: Obesity, Overweight

Interventions: Orforglipron, Placebo

Countries: United States, Argentina, China, Czechia, Germany, Japan, Puerto Rico

The main purpose of this study is to see how orforglipron, compared with placebo, helps reduce body weight in participants with obesity or with overweight and at least one other related health condition (excluding type 2 diabetes). This trial is part of the master protocol study J2A-MC-GZPO (NCT06993792). Participation in the study will last about 18 months.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Have body mass index (BMI) ≥30 kilograms per square meter (kg/m2) or BMI ≥25.0 kg/m2 and at least 1 of the following weight-related comorbidities at screening:

  * hypertension
  * dyslipidemia
  * obstructive sleep apnea, or
  * cardiovascular disease
* Have a history of at least one unsuccessful dietary effort to lose body weight

Exclusion Criteria:

* Have type 1 diabetes, type 2 diabetes, or any other types of diabetes
* Have an unstable body weight within 90 days prior to screening
* Have New York Heart Association functional classification IV congestive heart failure or an acute cardiovascular condition within 90 days prior to screening
* Have acute or chronic hepatitis or pancreatitis
* Are taking other medications or alternative remedies to manage weight loss

Locations (80)

Sun City West, Arizona, United States
Tucson, Arizona, United States
San Ramon, California, United States
Santa Ana, California, United States
Thousand Oaks, California, United States
DeLand, Florida, United States
Fort Lauderdale, Florida, United States
Hialeah, Florida, United States
Hollywood, Florida, United States
Ocoee, Florida, United States
Tampa, Florida, United States
Winter Park, Florida, United States
Decatur, Georgia, United States
Decatur, Georgia, United States
Savannah, Georgia, United States
Woodstock, Georgia, United States
Meridian, Idaho, United States
New Iberia, Louisiana, United States
Rockville, Maryland, United States
Silver Spring, Maryland, United States
Bay City, Michigan, United States
Missoula, Montana, United States
Carson City, Nevada, United States
Las Vegas, Nevada, United States
Chapel Hill, North Carolina, United States
Charlotte, North Carolina, United States
Fayetteville, North Carolina, United States
Corvallis, Oregon, United States
Philadelphia, Pennsylvania, United States
Smithfield, Pennsylvania, United States
+ 50 more on CT.gov