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Platform Study to Evaluate the Efficacy and Safety of Investigational Compound(s) in Patients With Moderate to Severe Atopic Dermatitis

NCT06947993

RecruitingPhase 2

Sponsor: Novartis Pharmaceuticals

Conditions: Atopic Dermatitis

Interventions: GHZ339, Placebo

Countries: United States, Argentina, Canada, China, Czechia, France, Germany, Hungary

This trial is designed to evaluate multiple compounds in participants with moderate to severe atopic dermatitis (AD).

Eligibility overview

Sex: ALL

Age: 18 Years to 100 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Key Inclusion Criteria of the master protocol:

* Able and willing to sign the informed consent (IC)
* Patients with a diagnosis of AD and onset of disease for at least 1 year
* Moderate to severe AD

Key Exclusion Criteria of the master protocol:

* Participants with a clinically significant medical condition or infectious disease (specified in sub-protocol)
* Participants with clinically significant abnormal hematology, clinical chemistry, or urine test results or clinically significant abnormal ECG
* Participant with any other active inflammatory skin disease
* Participants with any chronic, uncontrolled medical condition, which would put the participant at increased risk during the study (e.g., uncontrolled: diabetes, hypertension)
* Participants with any clinically unstable disease states that would likely require systemic corticosteroids (e.g., uncontrolled asthma)

Additional inclusion and exclusion criteria may apply depending on the intervention specific requirements

Locations (105)

Birmingham, Alabama, United States
Birmingham, Alabama, United States
Fort Smith, Arkansas, United States
Fountain Valley, California, United States
Los Angeles, California, United States
Sacramento, California, United States
Santa Ana, California, United States
Santa Monica, California, United States
Washington D.C., District of Columbia, United States
Miami, Florida, United States
St. Petersburg, Florida, United States
Atlanta, Georgia, United States
Macon, Georgia, United States
Louisville, Kentucky, United States
Brighton, Massachusetts, United States
Troy, Michigan, United States
Saint Joseph, Missouri, United States
Portsmouth, New Hampshire, United States
Brooklyn, New York, United States
Arlington, Texas, United States
Cypress, Texas, United States
Dallas, Texas, United States
Houston, Texas, United States
San Antonio, Texas, United States
Caba, Buenos Aires, Argentina
Caba, Buenos Aires, Argentina
Rosario, Santa Fe Province, Argentina
Edmonton, Alberta, Canada
Hamilton, Ontario, Canada
Markham, Ontario, Canada
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