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Radio- KO Radiotherapy for Knee Osteoarthritis Clinical Trial

RecruitingNA

Sponsor: Mayo Clinic

Conditions: Osteoarthritis, Knee

Interventions: Low dose radiotherapy, Sham comparator

Countries: United States

The primary aim of this study is to investigate whether low-dose radiotherapy is an effective treatment to reduce the pain of knee osteoarthritis. A secondary aim is to determine whether patients experience any more measurable side effects than those receiving sham treatments.

Eligibility overview

Sex: ALL

Age: 50 Years to 100 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* • patient's primary care provider is at Mayo Clinic in Rochester, MN

  * age 50-100 years
  * ICOAP pain scale A1 at least moderate intensity or B6 at least moderate intensity
  * diagnosed with primary knee OA ICD-10 codes M17.x

    o You have not had recurrent episodes of sudden onset of warmth, redness, or swelling of the affected knee
  * physical exam findings of medial or lateral joint line tenderness on palpation that is in the same location as the knee pain.
  * absence of primary knee pain in the pes anserine or hamstring or gastrocnemius, quadriceps, or patellar tendons on exam.
  * radiographic Kellgren-Lawrence grade 2-3 on 4-view knee x-rays taken within the last year ability to complete surveys electronically by email

Exclusion Criteria:

* • Kellgren-Lawrence grade 1 or 4

  * pregnancy or women 54 years and younger with potential for pregnancy (if they or their partner have not had tubal ligation, hysterectomy, or vasectomy)
  * history of ipsilateral intraarticular knee surgery
  * use of injected corticosteroids within 3 months or hyaluronans within 6 months or within 1 month if there was no sustained improvement post-injection of either corticosteroid or hyaluronan.
  * history of trauma to this knee in the last year that clearly caused the pain now present
  * history of RA, gout, pseudogout, hemarthroses (eg, hemophilic arthropathy) or other inflammatory arthritis involving this knee
  * history of symptomatic hip OA
  * history of psychosis, personality disorder, uncontrolled affective disorder
  * history of fibromyalgia
  * malignancy requiring active treatment current regular use of opiate analgesics, PRP, or acupuncture for the knees

Locations (1)

Rochester, Minnesota, United States