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The Locus Coeruleus, Norepinephrine and Cognitive Aging

Active Not RecruitingNA

Sponsor: Cornell University

Conditions: Alzheimer Disease

Interventions: t-VNS transcutaneous auricular vagus nerve stimulator

Countries: United States

The locus coeruleus (LC) has recently been identified as one of the earliest sites of damage in AD with pathological lesions appearing as early as the mid-20s. In this study, the investigators use a variety of techniques including structural MRI, functional MRI, pupillometry, and transcutaneous vagus nerve stimulation to assess the health of the LC and its relation to easily measurable peripheral variables.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* 18+ years of age
* Able to speak and understand English
* Hearing and vision correctable to normal or near-normal
* Willing and able to use a touchscreen
* Willing and able to use a keyboard and mouse
* Willing and able to undergo a MRI scan at the Cornell MRI Facility lasting approximately 90 minutes.

Exclusion Criteria:

* Moderate or severe brain injury
* Serious neurological disorders such as epilepsy
* Recent concussion
* Colorblindness
* Use of street drugs
* Cardiac arrhythmias

Locations (1)

Ithaca, New York, United States