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Phase 2b Study of EVO756 in Adults With Moderate to Severe Chronic Spontaneous Urticaria (CSU)

CompletedPhase 2

Sponsor: Evommune, Inc.

Conditions: Chronic Spontaneous Urticaria

Interventions: EVO756, EVO756, EVO756, Placebo control

Countries: United States, Canada, Japan

This study will evaluate the efficacy and safety of different doses of EVO756 in adults with moderate to severe chronic spontaneous urticaria (CSU).

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Confirmed CSU diagnosis for at least 3 months with an inadequate response to H1-antihistamines.
* Subjects who are taking H1-antihistamines must be on a stable regimen 4 weeks prior to Day 1 and while on study.
* Urticaria Activity Score (UAS7) equal to or greater than 16 at Day 1. UAS entries must be completed for a minimum of 4 out of the 7 days prior to Day 1.

Exclusion Criteria:

* Any clinically significant abnormality in laboratory evaluations, physical examinations, vital signs, or ECG at Screening, according to the Investigator's discretion.
* Use of certain medications.
* History of diseases with urticaria or angioedema symptoms, other than CSU and symptomatic dermographism.
* Significant medical history other than CSU, or any other condition which might interfere with the evaluation of CSU.

Locations (53)

Birmingham, Alabama, United States
Mobile, Alabama, United States
Fremont, California, United States
Lancaster, California, United States
Northridge, California, United States
Santa Rosa, California, United States
Upland, California, United States
Ventura, California, United States
Fort Myers, Florida, United States
Tampa, Florida, United States
Normal, Illinois, United States
Plainfield, Indiana, United States
West Des Moines, Iowa, United States
Hutchinson, Kansas, United States
Lexington, Kentucky, United States
Louisville, Kentucky, United States
Baton Rouge, Louisiana, United States
Lafayette, Louisiana, United States
New Orleans, Louisiana, United States
Baltimore, Maryland, United States
Boston, Massachusetts, United States
Northville, Michigan, United States
Wildwood, Missouri, United States
Woodbury, New York, United States
Asheville, North Carolina, United States
Charlotte, North Carolina, United States
Statesville, North Carolina, United States
Boardman, Ohio, United States
Canal Winchester, Ohio, United States
Cincinnati, Ohio, United States
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