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Virtual Reality Rehabilitation for Cognitive, Emotional, and Motor Recovery in Neurological Disorders

Active Not RecruitingNA

Sponsor: IRCCS Centro Neurolesi Bonino Pulejo

Conditions: Acquired Brain Injuries, Spinal Cord Injury, Multiple Sclerosis, Parkinson Disease

Interventions: VR Training, traditional cognitive and motor rehabilitation following standard clinical practices

Countries: Italy

This randomized controlled trial (RCT) evaluates the effectiveness of virtual reality (VR) rehabilitation in improving cognitive, emotional, social, and motor functions in patients with neurological disorders (ABI, SCI, MS, PD). It investigates whether VR improves motor and cognitive functions more than traditional therapy, identifies neurophysiological changes (EEG, fNIRS, MRI), and assesses the integration of VR with NIBS or telerehabilitation. Conducted over three years at IRCCS Centro Neurolesi Bonino Pulejo, participants are randomly assigned to either a VR training group or an active control group receiving traditional rehabilitation. Procedures include baseline assessments (T0), 20 rehabilitation sessions over 8 weeks, post-intervention evaluations (T1), and a 3-month follow-up (T2). Primary outcomes measure motor and cognitive function (MoCA, MMSE, FIM, TUG, Berg Balance Scale), neurophysiological changes (EEG, MRI, fNIRS, motion analysis), and emotional/social function (Empathy Quotient, Hamilton Depression Scale).

Eligibility overview

Sex: ALL

Age: 18 Years to 75 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Age: 18 to 75 years
* Diagnosis:

Parkinson's Disease (PD) (MDS Clinical Diagnostic Criteria) Multiple Sclerosis (MS) (McDonald Criteria) Spinal Cord Injury (SCI) (ASIA Impairment Scale) Acquired Brain Injury (ABI) (WHO Criteria for Stroke)

* Education: Minimum of 5 years of formal education
* Cognitive and physical ability to engage in rehabilitation

Exclusion Criteria:

* Major psychiatric disorders (e.g., psychosis, severe depression, anxiety disorders)
* Severe medical conditions that impair participation
* Sensory or motor impairments preventing VR interaction
* Contraindications for MRI (e.g., pacemakers, incompatible implants)
* Pregnancy

Locations (2)

Messina, Italy/Me, Italy
Messina, Italy/Me, Italy