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Sponsor: Harokopio University
Conditions: Hypercholesterolemia, Overweight/Obesity
Interventions: Control, Intervention
Countries: Greece
The goal of this clinical trial is to find out the possible beneficial effects of a white wheat bread enriched with oat beta-glucans on mildly hypercholesterolemic subjects with overweight/obesity. The main questions it aims to answer are: Does the enriched bread lower total and LDL-cholesterol levels as well as the levels of inflammatory factors of the participants? Does the enriched bread positively change the composition of gut microbiota? Researchers will compare the enriched bread to a common white wheat bread to see if the enriched bread provides additional effect beyond a hypocaloric dietary plan that the participants of both groups are going to follow. Participants will: Take the enriched or the common bread every day for 8 weeks. Visit the clinic once every 2 weeks for checkups and tests.
Sex: ALL
Age: 25 Years to 60 Years
Healthy volunteers: No
Study type: INTERVENTIONAL
Inclusion Criteria: * no underlying diseases * with LDL-cholesterol levels between 115-150 mg/dL * with 25\<BMI\<32 kg/m2 * with stable body weight in the last 3 months before the intervention * with normal diet and exercise habits Exclusion Criteria: * not suffer from diabetes mellitus, cardiovascular disease, chronic renal failure * not receive hypolipidemic treatment * not receive nutritional supplements that may affect blood lipid levels (eg omega-3 supplements, plant sterols/stanols) or the intestinal microbial flora (probiotics/prebiotics/antibiotics). * not be pregnant or lactating * not have food allergies * not have habits that prevent their compliance with the research protocol
- Athens, Attica, Greece