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Sponsor: Saglik Bilimleri Universitesi
Conditions: Rehabilitation, Pulmonary Rehabilitation, Long Noncoding RNA, Exercise, Asthma
Interventions: Resistive threshold inspiratory muscle training device, Standard pulmonary rehabilitation programme, No intervention
Countries: Turkey (Türkiye)
The goal of this observational study is to examine the effects of traditional respiratory rehabilitation and respiratory muscle strengthening training added to this program at the genetic level in asthma. The main questions it aims to answer are: * Does respiratory muscle strengthening exercise added to respiratory rehabilitation in asthmatic patients have additional benefits on rehabilitation outcome measures such as exercise capacity, shortness of breath, and muscle strength? * Does the gain obtained with respiratory muscle strengthening in asthmatic patients increase the quality of life of patients and have a positive effect on their psychological state? * Does respiratory rehabilitation applied to asthmatic patients have an effect on genetic changes? * Does respiratory muscle strengthening training applied in addition to respiratory rehabilitation in asthmatic patients have an effect on genetic changes? * Participants will be included in two different respiratory rehabilitation programs with and without respiratory muscle training, and pre- and post-treatment rehabilitation criteria and genetic changes will be compared.
Sex: ALL
Age: 18 Years to 75 Years
Healthy volunteers: Yes
Study type: INTERVENTIONAL
Inclusion Criteria: * Being between the ages of 18 and 75, * Being diagnosed with severe persistent asthma by a chest physician in accordance with the Global Initiative for Asthma (GINA) guideline criteria, * Patients with type 2 inflammation markers. According to the accepted standard; Peripheral eosinophils ≥150/µL and/or induced sputum eosinophils ≥2% - Airway hyperresponsiveness (PC20 methacholine \< 8 mg/mL) and/or bronchodilator response (\>12% or 200 mL improvement in % predicted FEV1 following 400 mg salbutamol inhalation) Exclusion Criteria: * Having had a recent (within the last month) respiratory tract infection, * Having a smoking history of over 10 packs/years or having a smoking history within 6 months of quitting smoking, * Having received oral corticosteroid treatment within the last 4 weeks, * Having a Body Mass Index \>30, * Eosinophilic Granulomatosis with Polyangiitis (EGPA) and Allergic Bronchopulmonary Aspergillosis (ABPA), * Vasculitis, * History of malignancy, * Pregnancy, * Presence of a musculoskeletal, neurological or cardiac disease that would prevent exercise.
- Istanbul, Turkey (Türkiye)