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Polycystic Kidney Disease 1 (PKD1) Gene Variant Groups in Autosomal Dominant Polycystic Kidney Disease
Polycystic Kidney Disease 1 (PKD1) Gene Variant Groups in Autosomal Dominant Polycystic Kidney Disease

NCT06747572

Active Not RecruitingN/A

Sponsor: Vertex Pharmaceuticals Incorporated

Conditions: Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Countries: United States, Belgium, Canada, France, Germany, Netherlands, Puerto Rico, Spain

The purpose of this study is to estimate the prevalence, demographic, and clinical characteristics of PKD1/2 gene variant groups in the ADPKD population.

Eligibility overview

Sex: ALL

Age: 12 Years to 65 Years

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria
Key Inclusion Criteria:

* Estimated glomerular filtration rate (eGFR) greater than or equal to (≥) 30 milliliter per minute (mL/min)/1.73 m\^2
* Willing and able to comply with scheduled visits and other study procedures
* A pre-existing diagnosis of ADPKD as defined in the protocol

Key Exclusion Criteria:

* History of kidney disease other than ADPKD that in the opinion of the investigator would independently impact the natural history of ADPKD
* History of solid organ or bone marrow transplantation or nephrectomy
* Ongoing renal replacement therapy or planning to start renal replacement therapy less than or equal to (≤)12 months from the Genotyping Visit in Part A

Other protocol defined Inclusion/Exclusion criteria will apply.
Locations (45)
  • Alabaster, Alabama, United States
  • Birmingham, Alabama, United States
  • Los Angeles, California, United States
  • Los Angeles, California, United States
  • San Francisco, California, United States
  • Middlebury, Connecticut, United States
  • New Haven, Connecticut, United States
  • Inverness, Florida, United States
  • Jacksonville, Florida, United States
  • Atlanta, Georgia, United States
  • Columbus, Georgia, United States
  • Chicago, Illinois, United States
  • Iowa City, Iowa, United States
  • Kansas City, Kansas, United States
  • Baltimore, Maryland, United States
  • Boston, Massachusetts, United States
  • Boston, Massachusetts, United States
  • Farmington Hills, Michigan, United States
  • Minneapolis, Minnesota, United States
  • Rochester, Minnesota, United States
  • Las Vegas, Nevada, United States
  • New York, New York, United States
  • Danville, Pennsylvania, United States
  • Philadelphia, Pennsylvania, United States
  • Nashville, Tennessee, United States
  • Burlington, Vermont, United States
  • Seattle, Washington, United States
  • Brussels, Belgium
  • Leuven, Belgium
  • Hamilton, Canada
  • + 15 more on CT.gov