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Sponsor: Institut Investigacio Sanitaria Pere Virgili
Conditions: Multiple Sclerosis
Interventions: cognitive stimulation through games
The primary objective of the study is to determine if the training for 6 months with a specific set of games ( previously selected according to the cognitive domain stimulate : attention, memory , executive functions and processing speed ) , so improve significant neuropsychological performance of patients with Multiple Sclerosis Sender Recurrent ( RRMS ) and secondary progressive multiple sclerosis (SPMS ) , your mood and your quality of life. Design : randomized clinical trial with a control group , coordinated a multicenter sample preselected patients.
Sex: ALL
Age: 18 Years to 65 Years
Healthy volunteers: No
Study type: INTERVENTIONAL
Inclusion Criteria: * Clinical diagnosis of RRMS or SPMS according to Poser criteria (1983) and McDonald (2001). * Degree of disability between 1 ( clinical signs without disability) and 5.5 (capable of walk 100 meters without aid or rest , disability severe enough to prevent the activities of the whole ) day as the Disability Scale Kurtze (EDSS , 1983). * Basic treatment for first-line MS ( immunomodulators). * Complaints cognitive, functional gradation in the scale of dementia GDS ( Global Dementia Staging ) of Reisberg (1982 ) 2 and 4 . * Patients who have mild to moderate cognitive impairment (have between 20 and 40 % of the altered neuropsychological tests). * Signed informed consent . Exclusion Criteria: * Cognitive impairment associated with other medical diseases (Alzheimer's, stroke, Parkinson's disease, kidney disease, respiratory, hepatic, endocrine or hematological). * Diagnosis of primary psychiatric disease with cognitive impairment in accordance with DSM-IV-TR criteria: schizophrenia, bipolar disorder, personality… * Diagnosis or history of substance abuse or dependence. * Score the Beck Depression Inventory II (BDI-II) greater than or equal to 30. * Low Intelectual coeficient, inferred through obtaining a scale score less than 4 on the Vocabulary subtest of the WAIS-IV. * Evidence of delusions, confusion or other disturbances of consciousness. * Severe sensory deficits (visual and / or auditory)or functional illiteracy in which neuropsychological study can not be carried out. * Patients treated with immunosuppressive drugs base or second line. * Patients who are already receiving treatment or have cognitive rehabilitation received in the last 12 months.