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Guideline Directed Medical Therapy in Patients With Heart Failure

CompletedN/A

Sponsor: Massachusetts General Hospital

Conditions: Heart Failure

Countries: United States

The TEAM-MGH study will formerly evaluate impact of the GDMT Clinic versus matched usual care patients on the proportion of GDMT administration over a 12 week period in approximately 300 total patients with HF across the spectrum of LVEF (with a minimum of 150 with HFrEF). The study will also assess impact of the GDMT Clinic on health status, functional capacity, biomarker profiles, cardiac remodeling and cardiovascular events.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* Diagnosis of HF, including new onset disease
* Established cardiovascular follow up at MGH
* Receiving sub-optimal medical care defined as \<50% target doses of GDMT agents
* Age ≥18 years
* For HFpEF:

  * Presence of structural heart disease (LAVi \>34 mL/Kg2, E/e' \>14, or LVH)
  * Recent HF hospitalization or historical NT-proBNP \>300 pg/mL

Exclusion Criteria:

* Planned referral to the Advanced HF program
* Decompensated HF
* End-stage kidney disease

  * eGFR \<15 mL/min/1.73m2 or on renal replacement therapy
* Untreated severe valvular heart disease
* Advanced HF

  * Inotropic support
  * Transplant or MCS planned
  * Enrolled in hospice or palliative care
* Life expectancy \<12 months due to non-CV disease
* Pericardial constriction
* Hypertrophic cardiomyopathy
* Unwillingness or inability to take GDMT
* Pregnancy or breast feeding

Locations (1)

Boston, Massachusetts, United States