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Dietary Factors and Rheumatoid Arthritis Risk in the UK Biobank

Active Not RecruitingN/A

Sponsor: University of Leeds

Conditions: Rheumatoid Arthritis (RA)

Interventions: Dietary patterns, Food groups and Nutrients, Alcohol intake, Vitamin D status

Rheumatoid arthritis (RA) is the most common inflammatory arthritis, affecting around 1% of the UK population. It affects around 400,000 adults and is characterised by synovial inflammation, cartilage and bone damage that requires lifelong treatment and represents a significant burden for both the individual and society. Diet can affect inflammatory status and RA risk, with varying risks for men and women on specific diets. People with low to moderate consumption of alcohol may be at a lower risk of RA. Those who consume lower intakes of fruit and vegetables could be at a greater risk than those with adequate intakes. This research aims to better understand the role of diet in reducing RA risk in men and women in the United Kingdom. The research will use existing dietary and lifestyle data from the United Kingdom Biobank Study and hospital records of RA incidence.

Eligibility overview

Sex: ALL

Age: 40 Years to 70 Years

Healthy volunteers: Yes

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* Male or female
* Ages 40 to 70 years at time of recruitment
* Able to provide informed consent

Exclusion Criteria:

* Unable to link dietary and lifestyle data with hospital episode statistics
* Had a rheumatoid arthritis before or no the date of recruitment
* Withdrew consent during the study period
* Genetic sex differs to reported sex
* Outlier diet or anthropometric data (energy intake \<500 or \>5000 kcal/day or body mass index \<10 or \>60 kg/m2)