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Boosting Regional Integration for COP D Care Through Guided Implementation and Audit of Post Exacerbation Transition Bundle

NCT06646419

Active Not RecruitingN/A

Sponsor: AstraZeneca

Conditions: COPD

Countries: China

This is a cluster randomized interventional study. Intervention is implemented at a hospital level and will change overall daily practice. 36 county level hospitals are r an domized to the intervention group or control group at the ratio of 2:1 . Total subjects is 1368 and a size of 38 per hospital .

Eligibility overview

Sex: ALL

Age: 40 Years to 80 Years

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* Diagnosed COPD (post- bronchodilator FEV1/FVC \< 0.7)
* 40\~80 years
* CAT≥10
* At least two moderate or at least one severe exacerbation history in past 1 year
* Able to sign informed consent

Exclusion Criteria:

* Continuous triple inhalation therapy for ≥6 months at baseline (include single inhaler and multiple inhalers)
* Stable COPD (symptom such as cough, sputum and shortness of breath are mild or stable, clinical condition has basically returned to pre-exacerbation)
* Comorbidities require/contraindicate long-term use of glucocorticoid treatment: asthma, interstitial lung disease, sarcoidosis, cystic fibrosis, active tuberculosis recurrent aspiration pneumonia ect.
* Serious comorbidities threaten to life expected survival time no more than 1 year: severe heart disease, severe chronic liver, severe kidney disease, cerebrovascular disease with long-term bed rest and malignant tumours ect.
* Not living in the healthcare area
* Patients currently participating in any other interventional studies

Locations (37)

Anyang, China
Baise City, China
Beijing, China
Bijie, China
Changsha, China
Chenzhou, China
Chifeng, China
Chuzhou, China
Deyang, China
Fuyang, China
Hangzhou, China
Hefei, China
Jieyang, China
Jining, China
Jiujiang, China
Kaiyuan, China
Langfang, China
Langzhong, China
Leping, China
Nanchang, China
Nanchong, China
Neijiang, China
Qiannan, China
Qujing, China
Sanmenxia, China
Shaoyang, China
Suzhou, China
Tengzhou, China
Tieling, China
Wenzhou, China
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