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Screening Strategies Among High-risk Populations for Anal Cancer

RecruitingNA

Sponsor: Lisa Flowers

Conditions: Neoplasms, HPV-Related Anal Squamous Cell Carcinoma

Interventions: HRA + Biopsy, Anal Cytology, Genotyping of anal hrHPV infection, CINtec®PLUS

Countries: United States

The goal of the proposed research is to 1) examine the performance of emerging screening methods for anal high-grade squamous intraepithelial lesion (aHSIL), a precancerous condition of anal cancer, among populations at high risk for anal cancer and 2) characterize DNA methylation, immunologic response, and environmental factors associated with aHSIL.

Eligibility overview

Sex: ALL

Age: 30 Years to 80 Years

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* 30-80 years of age
* Individuals with chronic impaired immune status
* History of high-grade lower genital tract neoplasia (LGTN), Zubrod Performance Status of 0-2;

Exclusion Criteria:

* Patients treated for aHSIL less than 6 months before screening,
* History of anal cancer and pregnant women.

Locations (4)

Miami, Florida, United States
Miami, Florida, United States
Atlanta, Georgia, United States
Atlanta, Georgia, United States