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Prevalence of Antibodies and Cytokines in Participants With Chronic Granulomatous Disease

RecruitingN/A

Sponsor: Ensoma

Conditions: Chronic Granulomatous Disease (CGD)

Countries: United States, United Kingdom

This research study is designed to assess the prevalence of specific antibodies and inflammatory cytokines in adult and pediatric participants with CGD.

Eligibility overview

Sex: ALL

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* The participant must have been diagnosed with CGD based on the referring physician's confirmation that NADPH oxidase activity is ≤5% (i.e., the percentage of dihydrorhodamine-positive \[DHR+\] cells is ≤5% by flow cytometry) OR based on confirmed pathogenic mutation in a CGD associated gene (CYBB, CYBA, NCF1, NCF2, NCF4, or CYBC1).
* The participant or the participant's legally authorized guardian or representative (if applicable) must be capable of giving signed informed consent.
* The participant (with assistance from the participant's legally authorized guardian/representative or primary caregiver, if applicable) must be capable of complying with the requirements and restrictions listed in the protocol and informed consent form (ICF).

Exclusion Criteria:

* The participant has undergone an allogeneic bone marrow transplant or investigational gene therapy.
* The participant is unable to comply with the sample collection procedure based on investigator judgment.

Locations (52)

Montgomery, Alabama, United States
Phoenix, Arizona, United States
Little Rock, Arkansas, United States
Sacramento, California, United States
San Francisco, California, United States
Denver, Colorado, United States
Hartford, Connecticut, United States
Dover, Delaware, United States
Washington D.C., District of Columbia, United States
Tallahassee, Florida, United States
Atlanta, Georgia, United States
Boise, Idaho, United States
Springfield, Illinois, United States
Indianapolis, Indiana, United States
Des Moines, Iowa, United States
Topeka, Kansas, United States
Frankfort, Kentucky, United States
Baton Rouge, Louisiana, United States
Augusta, Maine, United States
Annapolis, Maryland, United States
Boston, Massachusetts, United States
Lansing, Michigan, United States
Saint Paul, Minnesota, United States
Jackson, Mississippi, United States
Jefferson City, Missouri, United States
Helena, Montana, United States
Lincoln, Nebraska, United States
Carson City, Nevada, United States
Concord, New Hampshire, United States
Trenton, New Jersey, United States
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