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Sponsor: Azienda Ospedaliero-Universitaria di Modena
Conditions: ALS, FTD
Interventions: multiomic profile to assess genetic and environmental risk factiors
Countries: Italy
The goal of this study is to learn from discordant twins affected by Amyotrophic Lateral Sclerosis and/or Frontotemporal Dementia the contribution of genetic background versus environmental exposure. The main questions it aims to answer is: * How far does the genetic background explain the onset of ALS/FTD in discordant twins? * Which environmental factors and events occurring in post-fetal life influence the onset or progression of this neurodegenerative condition? Participants with ALS and/or FTD with a monozygotic or dizygotic twin willing to contribute to this research will be followed up for two years by specialized Motor Neuron Disorders centers in Italy, donating biological specimen for -omic sciences analysis, and checking out if prodromal signs/symptoms of these two conditions will develop during time.
Sex: ALL
Age: 18 Years to —
Healthy volunteers: Yes
Study type: OBSERVATIONAL
Inclusion Criteria: * Age \>18 yrs * Presence of MZ or DZ twins in the family both willing to participate in the study and able to provide informed consent * At least one twin is affected by ALS as defined by Gold Coast Criteria (Shefner et al., 2020) and/or by FTD as defined by Strong and colleagues (Strong et al., 2017) * Subjects able and willing to comply with study procedures as per protocol * Subjects able to understand, and capable of providing informed consent at screening visit before any protocol-specific procedures Exclusion Criteria: * Unwillingness to perform assessments as stated in the protocol at least during baseline visit for both twins * Unwillingness to donate biological samples collected at periphery (lumbar puncture excluded) for both twins * Women who are pregnant or breastfeeding
- Modena, Italy, Italy
- Palermo, Italy, Italy
- Torino, Italy, Italy