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Inclusion Criteria:

Participants eligible for inclusion in this study must fulfil all the following criteria:

* Male or female patients ≥18 years of age,
* At the Screening Visit, participants must be hospitalized for the first myocardial infarction. This must be a spontaneous MI (either ST-elevation MI or non-ST-elevation MI), which was not the result of percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG). Confirmation of MI is a combination of signs or symptoms consistent with presentation of MI, and at least one of the following (adapted from (Thygesen, et al., 2018)):

  * Documentation of cardiac biomarkers that exceed the diagnostic threshold of a local laboratory for MI
  * Pathological Q waves on ECG or other ECG changes as defined in Appendix 2
  * Imaging evidence of loss of viable myocardium or regional wall motion abnormality in a pattern consistent with an infarction or ischemic etiology
  * Identification of a coronary thrombus by angiography at the time of presentation with MI,
* LDL-C ≥ 1.8 mmol/L at the time of the hospitalization,
* Ability to participate in the hybrid educational program (must be able to receive emails and watch online educational videos),
* Patients must provide written consent to participate in the study.

Exclusion Criteria:

Participants meeting any of the following criteria are not eligible for inclusion in this study:

* History of previous myocardial infarction,
* History of previous coronary intervention due to ASCVD (percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG)),
* History of ischemic stroke,
* Any surgical or medical condition, which in the opinion of the investigator, may place the participant at higher risk from his/her participation in the study, or is likely to prevent the participant from complying with the requirements of the study or completing the study,
* Patients diagnosed with homozygous familial hypercholesterolemia,
* Unwillingness or inability (e.g., physical, or cognitive) to comply with study procedures (including adherence to study visits and fasting blood draws) and schedule,
* Participation in any other interventional study, both treatment and non-treatment interventional study,
* Patients treated with inclisiran prior to the hospitalization for myocardial infarction.

• Brno-Bohunice, Czechia
• České Budějovice, Czechia
• Ostrava Poruba, Czechia
• Prague, Czechia
• Prague, Czechia