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Inclusion Criteria:

* Age ≥18 at the time of signing the ICF.
* Provision of tumor sample to assess the PD-L1 expression (if applicable).
* ECOG performance status of 0 or 1.
* Measurable disease according to RECIST 1.1 (variations of RECIST 1.1 if applicable).
* Life expectancy ≥ 12 weeks.
* Adequate organ and bone marrow function.
* Body weight \> 35 kg
* Capable of giving signed informed consent.

Exclusion Criteria:

* Spinal cord compression.
* For sub-study 1,2,3,4, brain metastases unless asymptomatic, stable, and not requiring steroids for at least 14 days prior to start of study intervention. For sub-study 5, participants with untreated or progressive brain metastases.
* For sub-study 1,2,3, participants with primary neuroendocrine, mesenchymal, sarcomatoid histologies, or other histologies not mentioned as part of the inclusion criteria.
* Have not recovered (ie, ≤ Grade 1 or at baseline) from an AE due to a previously administered anti-cancer therapy.
* For sub-study 2, have had radiotherapy within 2 weeks prior to enrollment.
* For sub-study 3,4, participants have contraindications to any of the following drugs: 5-FU, paclitaxel and carboplatin
* History of another primary malignancy except for a) Malignancy treated with curative intent with no known active disease ≥2 years before the first dose of study intervention and of low potential risk for recurrence; b) Adequately treated nonmelanoma skin cancer or lentigo maligna, or carcinoma in situ without evidence of disease.
* Any evidence of diseases, and/or history of organ transplant or allogenic stem cell transplant, which makes it undesirable for the participant to participate in the study or that would jeopardize compliance with the protocol.
* Evidence of the following infections: active infection including tuberculosis; known HIV infection. that is not well controlled; active or uncontrolled HBV or HCV; or active hepatitis A.
* History of active primary immunodeficiency or active or prior documented autoimmune or inflammatory disorders.
* Participants who are candidates for curative therapy.
* Prior exposure to any immune-mediated therapy.
* Current or prior use of immunosuppressive medication within 14 days before the first dose of the study intervention is excluded. The following are exceptions to this criterion: a) Intranasal, inhaled, topical steroids, or local steroid injections (eg, intraarticular injection); b) Steroids as premedication for hypersensitivity reactions (eg, CT scan premedication or chemotherapy premedication) or a single dose for palliative purpose (eg, pain control).
* For sub-study 1,2,3,4, participants are ineligible if they have received any anti-cancer therapy within 28 days prior to the first dose of study intervention or within 5 half-lives of the respective agent, whichever is longer.
* Any concurrent chemotherapy except study intervention, radiotherapy, investigational, biologic, or hormonal therapy for cancer treatment.
* Radiotherapy treatment with a wide field of radiation or to more than 30% of the bone marrow within 4 weeks, prior to the first dose of study intervention.
* Major surgical procedures within 4 weeks prior to the first dose of the study intervention or still recovering from prior surgery.
* Receipt of live attenuated vaccine within 30 days prior to the first dose of the study intervention.
* Participants with a known allergy or hypersensitivity to any study intervention, on any excipients of any study intervention.
* For substudy 5: Participants with any prior systemic therapy, non-palliative radiotherapy, radical pleuropneumonectomy for pleural mesothelioma.

• Los Angeles, California, United States
• Baltimore, Maryland, United States
• New York, New York, United States
• Stony Brook, New York, United States
• Columbus, Ohio, United States
• Philadelphia, Pennsylvania, United States
• Clayton, Australia
• Nedlands, Australia
• Ijuí, Brazil
• Londrina, Brazil
• Natal, Brazil
• Porto Alegre, Brazil
• Santo André, Brazil
• São Caetano do Sul, Brazil
• Vitória, Brazil
• Vitória, Brazil
• Edmonton, Alberta, Canada
• Montreal, Quebec, Canada
• Anyang, China
• Beijing, China
• Beijing, China
• Beijing, China
• Beijing, China
• Beijing, China
• Bengbu, China
• Changchun, China
• Changchun, China
• Changsha, China
• Changsha, China
• Changsha, China
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