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Evaluation of the Relationship Between Optic Nerve Diameter and Optic Nerve Sheath Diameter Measured by Transorbital Sonography With Clinical, Radiological, and Electrophysiological Parameters in Multiple Sclerosis Patients

NCT06533930

CompletedN/A

Sponsor: Kutahya Health Sciences University

Conditions: Multiple Sclerosis

Interventions: Transorbital Sonography, Orbita Magnetic Resonance Imaging, Visual Evoked Potentials, Optical Coherence Tomography

Countries: Turkey (Türkiye)

The primary aim of this study is to evaluate the reliability of optic nerve diameter (OND) and optic nerve sheath diameter (ONSD) measurements made with transorbital sonography (TOS) and magnetic resonance imaging (MRI) in patient groups that may progress with subclinical optic atrophy over time, such as those with multiple sclerosis (MS). The secondary aims of this study are to compare the relationship of TOS with visual evoked potentials (VEP) and optical coherence tomography (OCT) parameters used in the assessment of the afferent visual pathway in MS and its clinical subtypes and to evaluate the potential of TOS as a diagnostic and monitoring tool for detecting optic nerve atrophy, subclinical axonal loss, and clinical disability in MS.

Eligibility overview

Sex: ALL

Age: 18 Years to 50 Years

Healthy volunteers: Yes

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* Being between the ages of 18-65
* Having been diagnosed with Multiple Sclerosis
* Undergoing disease-modifying therapy (DMT) for more than 6 months
* EDSS score ≤ 7

Exclusion Criteria:

* Patients whose Multiple Sclerosis diagnosis is uncertain
* Having ocular pathology that may affect optic nerve measurements (e.g., glaucoma, high myopia, history of ocular surgery)
* Having major systemic diseases that may affect optic nerve measurements (e.g., diabetes mellitus, hypertension)
* EDSS score \> 7
* Having experienced a clinical relapse or optic neuritis within the last 6 months.

Locations (1)

Kütahya, Kütahya, Turkey (Türkiye)