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Dysfunction of Olfaction After COVID-19 Infection: Morphological and Histomolecular Investigation

RecruitingNA

Sponsor: Universitaire Ziekenhuizen KU Leuven

Conditions: Covid19, Olfactory Dysfunction

Interventions: Biopsy and Cytobrush

Countries: Belgium, Germany, Switzerland

Investigation of the mechanisms of persistent SARS-CoV-2 associated olfactory dysfunction (OD) in patients with well-documented olfactory function. The investigators plan to collect olfactory cleft biopsies and cytobrushes in COVID-19 patients and controls.

Eligibility overview

Sex: ALL

Age: 18 Years to 70 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Olfactory Dysfunction group: Presence of evident OD (Parosmia, Threshold-Discrimination-Identification (TDI)-score ≤24, Subjective abnormal quantitative olfactory function; measured by a visual analogue score (VAS) of smell impairment ≥5/10
* Control group: No OD (TDI-score \&gt;30.5.)

Exclusion Criteria:

* Presence of concomitant nasal mucosal pathology that might affect olfactory function or bias the study investigations
* Use of anticoagulation therapy
* Allergy to local anesthetics

Locations (7)

Brussels, Brussels Capital, Belgium
Leuven, Vlaams-Brabant, Belgium
Bruges, West-Vlaanderen, Belgium
Dresden, Dresden, Germany
Frankfurt am Main, Frankfurt, Germany
Geneva, Canton of Geneva, Switzerland
Zurich, Canton of Zurich, Switzerland