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Non-interventional Study of Patients With Transthyretin (ATTR) Amyloidosis
Non-interventional Study of Patients With Transthyretin (ATTR) Amyloidosis

NCT06465810

RecruitingN/A

Sponsor: AstraZeneca

Conditions: Transthyretin Amyloidosis, ATTR-CM, ATTRv-PN, ATTR, ATTR-Mixed

Interventions: Treatment of transthyretin (ATTR) amyloidosis in observational study setting

Countries: United States, Canada, China, Germany, Spain, United Kingdom

The MaesTTRo study aims to enroll a global cohort of patients with transthyretin (ATTR) amyloidosis to longitudinally observe the natural course of the disease and describe real-world treatment patterns and outcomes. In addition, information on the effectiveness of ATTR amyloidosis treatments, including eplontersen, which is a ligand-conjugated antisense oligonucleotide gene silencing treatment targeting activity against both the mutant and wild-type TTR protein, will be collected.

Eligibility overview

Sex: ALL

Age: 18 Years to 130 Years

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria
Inclusion Criteria:

* Patient willing and able to provide written informed consent to participate in the study
* Confirmed diagnosis of amyloid transthyretin (ATTR) amyloidosis
* Aged ≥18 years at the time of signing the informed consent
* Patient willing and able to participate in collection of electronic patient reported outcomes (PROs)

Exclusion Criteria:

* Concurrent participation in any interventional trial for ATTR amyloidosis
* Involvement in the planning and/or conduct of the current study
* Patients with evidence of primary or light chain amyloidosis (AL) or serum protein A amyloidosis (AA)
* Asymptomatic patients with ATTR amyloidosis and asymptomatic ATTR mutation carriers
Locations (89)
  • La Jolla, California, United States
  • Los Angeles, California, United States
  • San Francisco, California, United States
  • San Francisco, California, United States
  • New Haven, Connecticut, United States
  • Washington D.C., District of Columbia, United States
  • Chicago, Illinois, United States
  • Indianapolis, Indiana, United States
  • Baltimore, Maryland, United States
  • Boston, Massachusetts, United States
  • Boston, Massachusetts, United States
  • Boston, Massachusetts, United States
  • Rochester, Minnesota, United States
  • Kansas City, Missouri, United States
  • St Louis, Missouri, United States
  • New Brunswick, New Jersey, United States
  • Manhasset, New York, United States
  • New York, New York, United States
  • New York, New York, United States
  • New York, New York, United States
  • Durham, North Carolina, United States
  • Portland, Oregon, United States
  • Danville, Pennsylvania, United States
  • Philadelphia, Pennsylvania, United States
  • Philadelphia, Pennsylvania, United States
  • Greenville, South Carolina, United States
  • Germantown, Tennessee, United States
  • Nashville, Tennessee, United States
  • Dallas, Texas, United States
  • Houston, Texas, United States
  • + 59 more on CT.gov