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Exploring Pathology Related to Slowly Expanding Lesions Using Advanced Imaging

Enrolling By InvitationN/A

Sponsor: Turku University Hospital

Conditions: Multiple Sclerosis

Countries: Finland

This is an open, follow-up study to compare the performance of three critical imaging methods to detect chronic active lesions in Multiple Sclerosis (MS) in vivo.

Eligibility overview

Sex: ALL

Age: 18 Years to 80 Years

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* Signing the informed consent form
* MS diagnosis in accordance with McDonald 2017 criteria
* Available longitudinal brain MR images (minimum 1 year)
* Simultaneous QSM MRI sequence and TSPO-PET
* Lesions with iron rim/s

Exclusion Criteria:

* Patients with other neurodegenerative disease than MS
* Patients with other autoimmune disease than MS
* Patients with other significant or malignant underlying disease of any other organ system
* Patients that are pregnant or breast-feeding
* Corticosteroid treatment within 4 weeks of imaging
* Patients with significant abnormal findings other than MS in the screening MRI
* Patients with claustrophobia, or a history of moderate to severe anxiety disorder or panic attacks (which could potentially lead to preterm termination of the imaging)
* Contraindication to PET scan investigations
* Exposure to experimental radiation in the past 12 months such that radiodosimetry limits would be exceeded by participating in this study
* Intolerance to previous PET scans; i.e. previous hypersensitivity reactions to any PET ligand or imaging agent or failure to participate in and comply with previous PET scans

Locations (1)

Turku, Southwest Finland, Finland