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Neurophysiological Effects of Transcutaneous Electrical Nerve Stimulation in Persons With MS

Not Yet RecruitingNA

Sponsor: University Medical Center Groningen

Conditions: Fatigue, Walking, Difficulty, Multiple Sclerosis

Interventions: Transcutaneous Electrical Nerve Stimulation, Movement

Transcutaneous Electrical Nerve Stimulation (TENS) is a treatment that could potentially reduce walking problems and fatigue in persons with Multiple Sclerosis. However, extensive use of TENS in a clinical setting is hindered by a lack of neurophysiological understanding of the effects of TENS. The primary objective of this pilot study is therefore to investigate the effects of TENS on brain activity in pwMS measured with fMRI.

Eligibility overview

Sex: ALL

Age: 18 Years to 65 Years

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* age: 18-65 years
* EDSS score \< 7

Exclusion Criteria:

* metal or electrical implants
* BMI \> 40
* claustrophobia
* being pregnant
* having a psychiatric disorder
* having cognitive or communication problems which reduces the capacity to understand instructions
* having a neurological disorder other than MS
* having cardiac arrhythmia