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Stratification of Risks of Conversion of Radiologically Isolated Syndromes (RIS) by Identifying Biomarkers in Serum and Cerebrospinal Fluid.

NCT06395662

CompletedN/A

Sponsor: Centre Hospitalier Universitaire de Nīmes

Conditions: Radiologically Isolated Syndrome, Multiple Sclerosis

Interventions: Observational

Countries: United States, France

Radiologically isolated syndrome (RIS) often precedes Multiple Sclerosis (MS) but some patients have no symptoms. This study aims to use biological samples and magnetic resonance imaging (MRI) data from four large cohorts of patients with MS in the United States, Europe and France, to stratify the chances of RIS developing into MS. Identifying early biomarkers to predict greater disease severity would have a significant impact, not only on RIS but also on the entire clinical spectrum of multiple sclerosis.

Eligibility overview

Sex: ALL

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* Patients from the OFSEP, SFSEP, RISE and TERIS cohorts with centralized validated radiologoically isolated syndrome and a standardized magnetic resonance imaging from the OFSEP or Randomized Clinical Trials database.
* at least one cerebro-spinal fluid and/or serum sample at baseline available at a local or centralized biological resource center.
* if present, serum sample collected at the time of clinical conversion.

Exclusion Criteria:

* patients with no biocollection, or with non-standardized magnetic resonance imaging acquisitions

Locations (3)

Dallas, Texas, United States
Nice, Alpes-Maritimes, France
Lyon, Rhône, France