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High Flow Nasal Cannula Rates in Pediatric Asthma

WithdrawnNA

Sponsor: University of Rochester

Conditions: Pediatric Asthma

Interventions: "High Flow" High Flow Nasal Cannula, "Low Flow" High Flow Nasal Cannula

Countries: United States

This is a randomized, open-label, 3-armed feasibility trial will examine conventional oxygen therapy (COT) vs high flow nasal cannula at 4L/min flow vs HFNC at 2L/kg/min flow (max 60L/min) in moderate to severe pediatric asthma exacerbations.

Eligibility overview

Sex: ALL

Age: 2 Years to 17 Years

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Age 2-17 years old with prior clinical diagnosis of asthma
* Admitted to PICU on standard asthma therapy defined as continuous albuterol and systemic corticosteroids
* Admitted to PICU on either COT or HFNC
* Admitted to PICU from either Golisano Children's Hospital ED or as a transport from an outside hospital ED within 6 hours of initial presentation
* PRAM score greater than or equal to 4 after completion of initial ED therapy

Exclusion Criteria:

* Admitted to the PICU on NIV or invasive mechanical ventilation
* Admitted to the PICU from general floors or \> 6 hours from initial presentation
* Presence of a tracheostomy or baseline NIV requirement
* Pregnancy
* Immunocompromised State

Locations (2)

Rochester, New York, United States
Rochester, New York, United States