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Kappa Index Versus Csf Oligoclonal Bands in Diagnosis of ms and Prediction of Disease Activity

UnknownN/A

Sponsor: Assiut University

Conditions: Multiple Sclerosis

Interventions: kappa index

To: 1. Compare the diagnostic performance of cerebrospinal fluid kappa index to that of cerebrospinal fluid IgG oligoclonal bands in differentiating multiple sclerosis from other inflammatory and non-inflammatory neurological diseases . 2. Assess the role of kappa free light chain and oligoclonal bands in predicting disease activity (conversion from clinical isolated syndrome to multiple sclerosis)

Eligibility overview

Sex: ALL

Age: 18 Years to 40 Years

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* Patients diagnosed with CIS or MS according to the 2017 revision of the McDonald criteria
* Patients diagnosed with RIS (Radiological isolated syndrome) according to the criteria by Okuda
* Age between 18 and 40 years.

Exclusion Criteria:

* History of exposure, in the 30 days prior to CSF collection, to immunosuppressant or immunomodulatory therapies .
* Peripheral neurological disorders .
* Infectious CNS disease.
* CNS tumor.
* Monoclonal gammopathy .
* Chronic kidney injury (GFR \<30 ml /min/1.75m2 )