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Inspiratory Muscle Training on The Severity of Exercise-Induced Bronchoconstriction and Time-Trial Performance (IMT_EIB)

NCT06336681

CompletedNA

Sponsor: Indiana University

Conditions: Exercise Induced Bronchospasm, Exercise Induced Asthma

Interventions: PrO2Fit Device

Countries: United States

Due to the lack of studies examining the impact of inspiratory muscle training (IMT) on the severity of exercise-induced bronchoconstriction (EIB) and exercise performance, the specific aim of this study is to assess the efficacy of flow-resistive IMT on EIB severity and symptoms, short-acting beta-2-agonist medication use, operating lung volumes, respiratory and limb locomotor muscle deoxygenation during constant-load cycling exercise, exertional dyspnea, and cycling time-trial performance.

Eligibility overview

Sex: ALL

Age: 18 Years to 35 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Male and female, between the ages of 18 to 35 years.
* Required to be a competitive recreational or college athlete and have at least 1-2 years of cycling or biking experience.
* Body Mass Index (BMI) of 18.5 to 28 kg/m\^2
* Considered "moderately to highly active" by the International Physical Activity Questionnaire (IPAQ).
* Have clinically treated mild to moderate persistent asthma and/or exercise-induced bronchoconstriction (EIB), with a resting forced expiratory volume in 1 second (FEV1) \> 65% of predicted.
* A ≥ 10% drop in FEV1 after eucapnic voluntary hyperpnea (EVH).
* Prescribed short-acting β2-agonists (SABAs) by a physician.
* Comfortable not taking SABA before experimental visits.

Exclusion Criteria:

* History of smoking or recreational smoking, cardiovascular disease, renal disease, neurological disease, and metabolic disease.
* Currently taking asthma maintenance medications (e.g., corticosteroids and leukotriene modifiers)
* Any injuries in the past 6 months.
* Taking selective serotonin reuptake inhibitors (SSRI)'s (antidepressants and anxiety medication), attention-deficit hyperactivity disorder (ADHD) medication, and chronically consume pain medication (Aleve, Tylenol, cannabidiol (CBD), etc.).
* Has had or is positive for COVID-19.
* Resting blood pressure of \> 130 mmHg systolic or 90 mmHg diastolic.
* Resting Pulse rate of \> 100 bpm.
* Regularly consuming fish oil supplements or eating more then one fish meal per week

Locations (1)

Bloomington, Indiana, United States