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Inclusion Criteria:

* Diagnosis of SLE according to the 2019 ACR/EULAR criteria
* Documentation of SLE autoantibodies
* Active SLE disease, as demonstrated by a SLEDAI-2K ≥ 4 at screening
* Failure to respond to standard-of-care medicines for the treatment of SLE as detailed in the protocol
* Immunization against pneumococcus, meningococcus, influenza, and COVID-19

Exclusion Criteria:

* Severe SLE-related organ damage dysfunction or life-threatening disease at screening.
* Any acute, severe lupus-related flare during screening that needs immediate treatment such as acute CNS lupus (e.g., psychosis, epilepsy) or catastrophic antiphospholipid syndrome.
* Presence of severe lupus kidney disease as defined by worsening proteinuria or estimated glomerular filtration rate (eGFR) which in the opinion of the Investigator requires immunosuppressive induction or maintenance treatment at screening.
* History or current diagnosis of ECG or cardiac abnormalities indicating a significant risk of safety for participants.
* Use of prohibited medication defined in the protocol.
* Clinically significant active, opportunistic, chronic or recurrent infection (including, HIV, HBV, HCV) confirmed one month prior to or during screening.
* Serious medical illness likely to interfere with participation in this clinical study.
* Women of child-bearing potential, defined as all women physiologically capable of becoming pregnant from menarche until becoming post-menopausal, unless they are using highly effective methods of contraception

Other protocol defined inclusion/exclusion criteria may apply.

• Beijing, China
• Beijing, China
• Berlin, Germany
• Mainz, Germany
• Budapest, Hungary
• Szeged, Hungary
• Leiden, South Holland, Netherlands
• Santiago Compostela, A Coruna, Spain
• Barcelona, Spain
• Madrid, Spain
• Bern, Switzerland