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Motor-cognitive Performance in People With Multiple Sclerosis

NCT06312046

RecruitingNA

Sponsor: Karolinska Institutet

Conditions: Multiple Sclerosis, Postural Balance

Interventions: HiBalance-MS

Countries: Sweden

Having a neurological disease such as multiple sclerosis (MS) leads to difficulties in balance and gait with or without concurrent performance of cognitive tasks, hindering activity performance and influencing the possibilities for an independent lifestyle. The investigators have adapted a previously developed balance training program to a highly challenging program specifically directed to MS (HiBalance-MS). This program was recently tested and found feasible in a pilot study. The investigators will now perform a randomized controlled trial in people with MS, in order to determine the effects of the program. The hypothesis is that progressively challenging balance exercise programs that are specific to the balance control domains affected by MS will be effective to improve balance control, walking, motor-cognitive performance, activity performance and health related quality of life.

Eligibility overview

Sex: ALL

Age: 18 Years to 65 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* an MS diagnosis according to McDonald criteria;
* an overall MS-disability score from 2.0 to 5.5 according to the Expanded Disability Status Scale;
* ability to walk 100 m without aid;
* a maximum score of 24 in the Mini-BESTest (i.e., \< 25 points)
* 18 to 65 years of age

Exclusion Criteria:

* cognitive impairment as indicated by a score \<21 in the Montreal Cognitive Assessment;
* presence of other conditions that would substantially influence balance;
* an MS relapse or change of disease-modifying treatment within the past 8 weeks

Locations (1)

Stockholm, Stockholm County, Sweden