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The Regulatory Role of miRNA 27 Follistatin Like Protein-1 Gene in Multiple Scelerosis

UnknownN/A

Sponsor: Assiut University

Conditions: Multiple Sclerosis

Interventions: micro RNA 27- FLP1 gene expression, The Expanded Disability Status Scale (EDSS), Electrophysiological assessment:, MRI examination MRI brain:

Multiple sclerosis (MS) is a neurodegenerative disease characterized by demyelination of the central nervous system. Young women between the ages of 20 and 40 are primarily targeted by this disabling disorder. Till now there are no sufficient mechanisms to explain the pathophysiology of multiple sclerosis.

Eligibility overview

Sex: FEMALE

Age: 20 Years to 45 Years

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

1. Patients diagnosed with MS based on the revised McDonald criteria.
2. Female patients will only be included.
3. 20- 45 years old.
4. Drug naïve.

Exclusion Criteria:

* 1\. Patients with other neurodegenerative and autoimmune disorders. 2. Pregnant females. 3. Co-existing chronic hypertension, diabetes, and epilepsy 4. chronic renal or hepatic diseases