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Cerebellar RTMS in Patients with Multiple Sclerosis

CompletedNA

Sponsor: Cairo University

Conditions: Patients with Multiple Sclerosis

Interventions: High frequency repetitive transcranial magnetic stimulation, Sham repetitive transcranial magnetic stimulation

Countries: Egypt

To determine the efficacy of high frequency cerebellar repetitive transcranial magnetic stimulation on coordination in patients with multiple sclerosis.

Eligibility overview

Sex: ALL

Age: 20 Years to 45 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Clinically definite MS (relapsing, remitting and secondary progressive) patients
* Patients who are medically stable and Free from relapses three months before
* Ambulant patients without an assistive device and score less than 5 on the Kurtzke Expanded Disability Status Scale (EDSS)
* Patients receiving their disease modifying drugs but no medication changing during the previous three months.
* Patients who had MRI evidence of lesions in the cerebellum or in the cerebellar pedunculi.
* Right handed patients.
* Severity of ataxia range from 4 to 10 according to scale of assessment and rating ataxia (SARA).
* Did not apply cerebellar transcranial magnetic stimulation before.

Exclusion Criteria:

* Any other neurological deficits or orthopedics abnormalities.
* Ataxic manifestations for other cause rather than Multiple Sclerosis.
* Other neurological manifestations (e.g. spasticity, visual loss)
* Secondary musculoskeletal complication such as contractures or deformities. Cardiovascular, pulmonary, hepatic, renal, hemopoietic and thyroid diseases.
* Pregnant women.
* Addicted individuals.
* Previous surgeries in the brain.
* Any magnetic or metallic devices implanted (like cochlear implants) .
* Psychotic deficits or history of epileptic seizures.

Locations (1)

Giza, Dokki, Egypt